Abstract
We studied the hypoglycemic effect of 4-hydroxybenzoic acid, a constituent of the root of Pandanus odorus Ridl. (Pandanaceae, Thai name: Toei-hom), in streptozotocin-diabetic rats. Oral administration of 4-hydroxybenzoic acid caused a decrease in plasma glucose levels dose-dependently in the diabetic rat. The constituent did not affect serum insulin level and liver glycogen content in the diabetic model, but increased glucose consumption in normal and diabetic rat diaphragms. These results suggest that 4-hydroxybenzoic acid produces a hypoglycemic effect mediated by an increase in the peripheral glucose consumption.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Blood Glucose / drug effects
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Blood Glucose / metabolism
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Diabetes Mellitus, Experimental / blood
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Diabetes Mellitus, Experimental / drug therapy
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Diaphragm / drug effects
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Diaphragm / metabolism
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Dose-Response Relationship, Drug
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Glucose / metabolism
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Hypoglycemic Agents / pharmacology*
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Hypoglycemic Agents / therapeutic use
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In Vitro Techniques
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Insulin / blood
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Liver Glycogen / metabolism
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Male
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Parabens / pharmacology*
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Parabens / therapeutic use
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Rats
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Rats, Wistar
Substances
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Blood Glucose
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Hypoglycemic Agents
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Insulin
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Liver Glycogen
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Parabens
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Plant Extracts
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Glucose
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4-hydroxybenzoic acid