Abstract
Cytomegalovirus infection (CMV) complicated the posttransplant course in 9 of 24 children after liver transplantation. We found specific antibodies (IgG and IgM) to be of very low value in diagnosis and monitoring of CMV infection after liver transplantation. Detection of CMV-DNA by PCR method in the blood or urine was very useful for diagnosis, but less for monitoring of the course of disease and its treatment. Measurements of early immediate CMV antigen (IEA), in peripheral blood leucocytes allowed for very early diagnosis of CMV infection and correlated well with the course of disease and response to treatment of the patient.
MeSH terms
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Antibodies, Viral / blood
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Antiviral Agents / therapeutic use
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Child
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Cytomegalovirus Infections / diagnosis*
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Cytomegalovirus Infections / drug therapy
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Cytomegalovirus Infections / physiopathology
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DNA, Viral / blood
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Enzyme-Linked Immunosorbent Assay
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Follow-Up Studies
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Ganciclovir / therapeutic use
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Hepatitis, Viral, Human / etiology
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Humans
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Immunoenzyme Techniques
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Immunoglobulin G / blood
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Immunoglobulin M / blood
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Leukocytes / virology
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Liver Transplantation*
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Monitoring, Physiologic
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Polymerase Chain Reaction
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Postoperative Complications / diagnosis
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Retrospective Studies
Substances
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Antibodies, Viral
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Antiviral Agents
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DNA, Viral
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Immunoglobulin G
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Immunoglobulin M
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Ganciclovir