Abstract
A series of new, highly potent and orally active "motilactides", 9-deoxo-4"-deoxy-6,9-epoxyerythromycin lactams was designed, synthesized, and evaluated for their gastrointestinal motor stimulating activity. These compounds were acid stable and showed good oral efficacy.
MeSH terms
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Administration, Oral
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Animals
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Biological Availability
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Dogs
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Epoxy Compounds / chemical synthesis*
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Epoxy Compounds / chemistry
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Epoxy Compounds / pharmacology
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Erythromycin / analogs & derivatives*
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Erythromycin / chemical synthesis*
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Erythromycin / chemistry
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Erythromycin / pharmacology
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Indicators and Reagents
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Molecular Structure
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Myoelectric Complex, Migrating / drug effects*
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Myoelectric Complex, Migrating / physiology
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Prodrugs / chemical synthesis
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Prodrugs / chemistry
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Prodrugs / pharmacology
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Receptors, Gastrointestinal Hormone / agonists
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Receptors, Neuropeptide / agonists
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Epoxy Compounds
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Indicators and Reagents
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Prodrugs
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Receptors, Gastrointestinal Hormone
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Receptors, Neuropeptide
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motilin receptor
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Erythromycin