Structural insight into the binding motifs for the calcium ion and the non-catalytic zinc in matrix metalloproteases

I Massova; L P Kotra; S Mobashery

doi:10.1016/s0960-894x(98)00128-0

Structural insight into the binding motifs for the calcium ion and the non-catalytic zinc in matrix metalloproteases

Bioorg Med Chem Lett. 1998 Apr 7;8(7):853-8. doi: 10.1016/s0960-894x(98)00128-0.

Authors

I Massova¹, L P Kotra, S Mobashery

Affiliation

¹ Department of Chemistry, Wayne State University, Detroit, MI 48202-3489, USA.

PMID: 9871554
DOI: 10.1016/s0960-894x(98)00128-0

Abstract

The binding motifs for the structural zinc and calcium ions in matrix metalloproteases (MMPs) were investigated by analyzing the three-dimensional structural models of 23 representative MMPs.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Amino Acid Sequence
Animals
Calcium / metabolism*
Catalytic Domain
Chickens
Humans
Matrix Metalloproteinases, Secreted
Metalloendopeptidases / chemistry*
Metalloendopeptidases / metabolism*
Models, Molecular
Molecular Sequence Data
Protein Structure, Secondary*
Ranidae
Salamandridae
Sequence Alignment
Sequence Homology, Amino Acid
Swine
Zinc / metabolism*

Substances

Matrix Metalloproteinases, Secreted
Metalloendopeptidases
matrix metalloproteinase 19
Zinc
Calcium