Nonpeptide glycoprotein IIb/IIIa inhibitors: substituted quinazolinediones and quinazolinones as potent fibrinogen receptor antagonists

N J Liverton; D J Armstrong; D A Claremon; D C Remy; J J Baldwin; R J Lynch; G Zhang; R J Gould

doi:10.1016/s0960-894x(98)00047-x

Nonpeptide glycoprotein IIb/IIIa inhibitors: substituted quinazolinediones and quinazolinones as potent fibrinogen receptor antagonists

Bioorg Med Chem Lett. 1998 Mar 3;8(5):483-6. doi: 10.1016/s0960-894x(98)00047-x.

Authors

N J Liverton¹, D J Armstrong, D A Claremon, D C Remy, J J Baldwin, R J Lynch, G Zhang, R J Gould

Affiliation

¹ Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA.

PMID: 9871603
DOI: 10.1016/s0960-894x(98)00047-x

Abstract

The synthesis and biological activity of a series of 3,6-substituted quinazolinediones and quinazolinones are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of these structures as central templates for nonpeptide RGD mimics.

MeSH terms

Humans
In Vitro Techniques
Platelet Aggregation Inhibitors / chemistry
Platelet Aggregation Inhibitors / pharmacology
Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors*
Quinazolines / chemistry
Quinazolines / pharmacology*
Structure-Activity Relationship

Substances

Platelet Aggregation Inhibitors
Platelet Glycoprotein GPIIb-IIIa Complex
Quinazolines