Abstract
Five new dihydroxamic acid ligands (L) (8, 10a, 10b, 10c and 13) have been synthesised and characterised as potential chelating agents for iron (Fe3+). The log stability constants of Fe2L3 and FeL+ from Fe3+ and L2- have been estimated to be log beta = 61.96 and log beta 1 = 22.8 respectively. The ability of these compounds to scavenge hydroxyl radicals (oOH) responsible for cell damage have been studied by esr spectroscopy.
MeSH terms
-
Electron Spin Resonance Spectroscopy
-
Free Radical Scavengers / chemical synthesis*
-
Free Radical Scavengers / chemistry
-
Free Radical Scavengers / pharmacology
-
Hydroxamic Acids / chemical synthesis*
-
Hydroxamic Acids / chemistry
-
Hydroxamic Acids / pharmacology
-
Hydroxyl Radical / chemistry*
-
Magnetic Resonance Spectroscopy
-
Siderophores / chemical synthesis*
-
Siderophores / chemistry
-
Siderophores / pharmacology
Substances
-
Free Radical Scavengers
-
Hydroxamic Acids
-
Siderophores
-
Hydroxyl Radical