Design and synthesis of bio-isosteres of thymidine triphosphate

A O Goldring; J Balzarini; I H Gilbert

doi:10.1016/s0960-894x(98)00189-9

Design and synthesis of bio-isosteres of thymidine triphosphate

Bioorg Med Chem Lett. 1998 May 19;8(10):1211-4. doi: 10.1016/s0960-894x(98)00189-9.

Authors

A O Goldring¹, J Balzarini, I H Gilbert

Affiliation

¹ Welsh School of Pharmacy, University of Wales Cardiff, U.K.

PMID: 9871737
DOI: 10.1016/s0960-894x(98)00189-9

Abstract

This paper describes the design and synthesis of potential isosteres of triphosphates which should show enhanced metabolic stability and lipophilicity compared to triphosphates. The triphosphate isosteres were then linked to nucleosides and evaluated for their inhibitory activity against HIV infection.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Computer Simulation
Drug Design
Indicators and Reagents
Models, Molecular
Molecular Conformation
Molecular Structure
Stereoisomerism
Thymine Nucleotides / chemical synthesis*
Thymine Nucleotides / chemistry*

Substances

Indicators and Reagents
Thymine Nucleotides
thymidine 5'-triphosphate