Abstract
The organic extract of the fermentation broth of a fungus was found to contain a depsipeptide SCH 58149 (1), containing three amino acids and a beta-hydroxy acid, by spectroscopic studies. The amino acids were phenyl alanine, alanine and leucine and the beta-hydroxy acid is 3-hydroxy-4-methyl octanoic acid. SCH 58149 exhibited weak activity against cholesterol ester transfer protein (CETP) with an IC50 of 50 microM.
MeSH terms
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Acremonium / metabolism*
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Amino Acids / analysis
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Carrier Proteins / antagonists & inhibitors*
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Cholesterol Ester Transfer Proteins
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Cholesterol Esters / metabolism*
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Depsipeptides*
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Fermentation
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Glycoproteins*
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Magnetic Resonance Spectroscopy
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Peptides, Cyclic / analysis
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Peptides, Cyclic / isolation & purification
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Peptides, Cyclic / pharmacology*
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Spectrometry, Mass, Fast Atom Bombardment
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Spectrophotometry, Ultraviolet
Substances
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Amino Acids
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Carrier Proteins
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Cholesterol Ester Transfer Proteins
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Cholesterol Esters
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Depsipeptides
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Glycoproteins
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Peptides, Cyclic
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SCH 58149