Abstract
SAR for antimicrobial activity against H. pylori was investigated in a new series of 2-alkylguanidino-4-furylthiazoles. Of the compounds obtained, cyclohexylmethyl and ethoxyethyl derivatives were identified as a novel class of anti-H. pylori agents which possessed potent and selective antimicrobial activity against H. pylori. These compounds also showed gastric antisecretory activity.
MeSH terms
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Animals
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology
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Dogs
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Gastric Acid / metabolism
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Guanidines / chemical synthesis*
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Guanidines / pharmacology
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Guinea Pigs
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Heart Atria / drug effects
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Helicobacter pylori / drug effects*
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Histamine H2 Antagonists / chemical synthesis*
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Histamine H2 Antagonists / pharmacology
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In Vitro Techniques
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Microbial Sensitivity Tests
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Rats
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Structure-Activity Relationship
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Thiazoles / chemical synthesis*
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Thiazoles / pharmacology
Substances
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Anti-Bacterial Agents
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Guanidines
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Histamine H2 Antagonists
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Thiazoles