N-[4-(1,1'-biphenyl)methyl]-4-(4-thiomorpholinylmethyl) benzenamines as non-oxazolidinone analogues of antimycobacterial U-100480

M Artico; A Mai; G Sbardella; S Massa; G Lampis; D Deidda; R Pompei

doi:10.1016/s0960-894x(98)00248-0

N-[4-(1,1'-biphenyl)methyl]-4-(4-thiomorpholinylmethyl) benzenamines as non-oxazolidinone analogues of antimycobacterial U-100480

Bioorg Med Chem Lett. 1998 Jun 16;8(12):1493-8. doi: 10.1016/s0960-894x(98)00248-0.

Authors

M Artico¹, A Mai, G Sbardella, S Massa, G Lampis, D Deidda, R Pompei

Affiliation

¹ Dipartimento di Studi Farmaceutici, Università di Roma La Sapienza, Italy. [email protected]

PMID: 9873376
DOI: 10.1016/s0960-894x(98)00248-0

Abstract

Thiomorpholine analogues of U-100480 with the biphenylmethyl group replacing the acetamidomethyloxazolidinone moiety have been synthesized and tested as antimycobacterial agents together with various related derivatives. Some biphenyl derivatives were endowed with high activity against Mycobacterium tuberculosis and other non-tuberculous mycobacteria.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetamides / chemistry
Acetamides / pharmacology*
Animals
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Chlorocebus aethiops
Microbial Sensitivity Tests
Mycobacterium / drug effects*
Oxazoles / chemistry
Oxazoles / pharmacology*
Species Specificity
Vero Cells

Substances

Acetamides
Anti-Bacterial Agents
Oxazoles
U 100480