Solid-phase synthesis of N-substituted amidinophenoxy pyridines as factor XA inhibitors

R Mohan; W Yun; B O Buckman; A Liang; L Trinh; M M Morrissey

doi:10.1016/s0960-894x(98)00333-3

Solid-phase synthesis of N-substituted amidinophenoxy pyridines as factor XA inhibitors

Bioorg Med Chem Lett. 1998 Jul 21;8(14):1877-82. doi: 10.1016/s0960-894x(98)00333-3.

Authors

R Mohan¹, W Yun, B O Buckman, A Liang, L Trinh, M M Morrissey

Affiliation

¹ Pharmaceuticals Discovery, Berlex Biosciences, Richmond, CA 94804, USA.

PMID: 9873451
DOI: 10.1016/s0960-894x(98)00333-3

Abstract

An arylamidine linker has been employed for the solid-phase synthesis of N-substituted amidinoaryloxypyridine analogs 2 via nucleophilic substitution on a fluoropyridyl template. Two novel N-substituted amidinoaryloxypyridine derivatives 2a and 2b were discovered via this approach.

MeSH terms

Factor Xa Inhibitors*
Pyridines / chemical synthesis*
Pyridines / chemistry
Pyridines / pharmacology*
Serine Proteinase Inhibitors / chemical synthesis
Serine Proteinase Inhibitors / chemistry
Serine Proteinase Inhibitors / pharmacology
Structure-Activity Relationship

Substances

Factor Xa Inhibitors
Pyridines
Serine Proteinase Inhibitors