Abstract
The synthesis and pharmacological profile of a novel series of potent and selective phosphodiesterase type IV (PDE IV) inhibitors is described.
MeSH terms
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3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors*
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Amides / chemical synthesis
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Amides / pharmacology
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Animals
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Anti-Asthmatic Agents / chemical synthesis*
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Anti-Asthmatic Agents / pharmacology*
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Carboxylic Acids / chemical synthesis
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Carboxylic Acids / pharmacology
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Cyclic Nucleotide Phosphodiesterases, Type 4
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Eosinophilia / drug therapy
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Guinea Pigs
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Phosphodiesterase Inhibitors / chemical synthesis*
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Phosphodiesterase Inhibitors / pharmacology*
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Quinolones / chemical synthesis
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Quinolones / pharmacology
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Structure-Activity Relationship
Substances
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Amides
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Anti-Asthmatic Agents
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Carboxylic Acids
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Phosphodiesterase Inhibitors
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Quinolones
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3',5'-Cyclic-AMP Phosphodiesterases
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Cyclic Nucleotide Phosphodiesterases, Type 4