The synthesis and biological activity of a novel series of diazepine MMP inhibitors

Bioorg Med Chem Lett. 1998 Oct 6;8(19):2657-62. doi: 10.1016/s0960-894x(98)00473-9.

Abstract

A novel series of diazepine-based hydroxamic acid inhibitors of MMP-1, MMP-9, and MMP-13 were prepared and evaluated both in vitro and in vivo.

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Azepines / metabolism*
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology*
  • Hydroxamic Acids / chemical synthesis
  • Hydroxamic Acids / pharmacology
  • Matrix Metalloproteinase 1
  • Matrix Metalloproteinase 9
  • Matrix Metalloproteinase Inhibitors*
  • Mice
  • Organic Chemicals*
  • Protease Inhibitors / pharmacology
  • Pyrazines*
  • Structure-Activity Relationship
  • Sulfonamides / chemical synthesis
  • Sulfonamides / pharmacology

Substances

  • Antineoplastic Agents
  • Azepines
  • CGS 27023A
  • Enzyme Inhibitors
  • Hydroxamic Acids
  • Matrix Metalloproteinase Inhibitors
  • Organic Chemicals
  • Protease Inhibitors
  • Pyrazines
  • Sulfonamides
  • prinomastat
  • Matrix Metalloproteinase 9
  • Matrix Metalloproteinase 1