Abstract
Novel compounds having a dual pharmacophore were synthesised and evaluated for their insulin sensitiser and anti-inflammatory properties in different animal models.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Blood Glucose / drug effects
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Butanones / pharmacology
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Chromans / pharmacology
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Edema / drug therapy
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Female
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Hypoglycemic Agents / chemical synthesis*
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Hypoglycemic Agents / pharmacology*
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Male
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Mice
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Nabumetone
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Rats
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Rats, Wistar
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Structure-Activity Relationship
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Thiazoles / chemical synthesis*
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Thiazoles / pharmacology*
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Thiazolidinediones*
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Troglitazone
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Blood Glucose
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Butanones
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Chromans
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Hypoglycemic Agents
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Thiazoles
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Thiazolidinediones
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Troglitazone
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Nabumetone
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netoglitazone