Synthesis and antibacterial activity of 2-alkoxy penems

Bioorg Med Chem Lett. 1998 Oct 6;8(19):2793-6. doi: 10.1016/s0960-894x(98)00502-2.

Abstract

The phosphite mediated Oxalimide cyclization reaction was extended to 4-dithiocarbonates of N-oxalyl-2-azetidinones to synthesize 2-alkoxy penems 3. In general, the in vitro antibacterial potency of compounds 3 was weak compared to the highly potent 2-alkylthiopenems 2.

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / pharmacology*
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Lactams
  • Microbial Sensitivity Tests

Substances

  • Anti-Bacterial Agents
  • Lactams