PDE4 inhibitors: new xanthine analogues

Bioorg Med Chem Lett. 1998 Oct 20;8(20):2925-30. doi: 10.1016/s0960-894x(98)00524-1.

Abstract

Novel xanthine analogues are described which are selective PDE4 inhibitors with improved therapeutic potential over theophylline.

Publication types

  • Comparative Study

MeSH terms

  • 3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors*
  • Animals
  • Cyclic Nucleotide Phosphodiesterases, Type 4
  • Eosinophilia / drug therapy
  • Ferrets
  • Guinea Pigs
  • Phosphodiesterase Inhibitors / adverse effects
  • Phosphodiesterase Inhibitors / chemical synthesis*
  • Phosphodiesterase Inhibitors / pharmacology
  • Skin Diseases / drug therapy
  • Theophylline / pharmacology
  • Vomiting / chemically induced
  • Xanthines / chemical synthesis*
  • Xanthines / pharmacology

Substances

  • Phosphodiesterase Inhibitors
  • Xanthines
  • Theophylline
  • 3',5'-Cyclic-AMP Phosphodiesterases
  • Cyclic Nucleotide Phosphodiesterases, Type 4