Synthesis of novel C7-aryl substituted pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) via pro-N10-Troc protection and Suzuki coupling

A Guiotto; P W Howard; P G Baraldi; D E Thurston

doi:10.1016/S0960-894X(97)10083-X

Synthesis of novel C7-aryl substituted pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) via pro-N10-Troc protection and Suzuki coupling

Bioorg Med Chem Lett. 1998 Nov 3;8(21):3017-8. doi: 10.1016/S0960-894X(97)10083-X.

Authors

A Guiotto¹, P W Howard, P G Baraldi, D E Thurston

Affiliation

¹ CRC Gene Targeted Drug Design Research Group, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, Hants, U.K.

PMID: 9873667
DOI: 10.1016/S0960-894X(97)10083-X

Abstract

Novel C7-aryl pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) have been synthesized via Suzuki coupling between a 7-Iodo N10-Troc-protected PBD carbinolamine and commercially available boronic acids.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibiotics, Antineoplastic / chemical synthesis*
Antibiotics, Antineoplastic / pharmacology
Benzodiazepines / chemical synthesis*
Benzodiazepines / pharmacology
Humans
Structure-Activity Relationship
Tumor Cells, Cultured

Substances

Antibiotics, Antineoplastic
Benzodiazepines