Abstract
Using an intramolecular [2 + 2] photocyclization, 2,4-methanopyrrolidine-2,4-dicarboxylate was prepared as a conformationally locked analogue of glutamate. This compound, in combination with two other pyrrolidine dicarboxylates, has been used to define the structural elements that differentiate substrate and nonsubstrate inhibitors of a high-affinity, sodium-dependent glutamate transporter.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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ATP-Binding Cassette Transporters / antagonists & inhibitors*
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Amino Acid Transport System X-AG
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Animals
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Dicarboxylic Acids / chemical synthesis*
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Glutamic Acid / analogs & derivatives*
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Male
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Molecular Conformation
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Pyrrolidines / chemical synthesis*
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Rats
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Rats, Sprague-Dawley
Substances
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2,4-methanopyrrolidine-2,4-dicarboxylate
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ATP-Binding Cassette Transporters
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Amino Acid Transport System X-AG
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Dicarboxylic Acids
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Pyrrolidines
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Glutamic Acid