Abstract
In the 3-oxo-1,4-benzodiazepine-2-acetic acid series of vitronectin receptor (alpha v beta 3) antagonists, a compound containing an imidazopyridine arginine mimetic was discovered which had sufficient potency and i.v. pharmacokinetics for demonstration of efficacy in a rat restenosis model.
MeSH terms
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Angioplasty, Balloon, Coronary / adverse effects*
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Animals
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Benzodiazepines / therapeutic use*
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Coronary Disease / drug therapy*
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Disease Models, Animal
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Imidazoles / therapeutic use*
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Pyridines / therapeutic use*
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Rats
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Receptors, Vitronectin / antagonists & inhibitors*
Substances
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Imidazoles
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Pyridines
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Receptors, Vitronectin
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Benzodiazepines