Growth inhibitory effect of juvenile hormone analogues on epimastigotes of Trypanosoma cruzi

Bioorg Med Chem Lett. 1998 Nov 17;8(22):3257-60. doi: 10.1016/s0960-894x(98)00590-3.

Abstract

Several compounds, structurally related to the insect growth regulator Fenoxycarb, exhibited interesting inhibition action to control proliferation of Trypanosoma cruzi, the parasite responsible for Chagas' disease. Some of these drugs were shown to be potent growth inhibitors of this parasite. All of these drugs had previously presented juvenoid activity on several non-related bug species such as Tenebrio molitor, Galleria mellonella, Dysdercus cingulatos, and Pyrrhocoris apterus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Juvenile Hormones / pharmacology*
  • Ketoconazole / pharmacology
  • Structure-Activity Relationship
  • Trypanocidal Agents / pharmacology*
  • Trypanosoma cruzi / drug effects*
  • Trypanosoma cruzi / growth & development

Substances

  • Juvenile Hormones
  • Trypanocidal Agents
  • Ketoconazole