Abstract
Hemodialysis permits a long term survival to patients with End Stage Renal Disease (E.S.R.D.). However the patients ongoing hemodialysis presented a immunodeficiency and a important modification of drugs biodisponibility. Tuberculosis is an endemic disease in our countries. Extrapulmonary tuberculosis is reported from these two cases among 13 patients treated in C.H.U.A. Le Dantec hemodialysis center. Clinical symptoms are not specific bacteria is not found. Diagnosis is obtained by a bundle of arguments. Antituberculosis treatment need to be adjusted in this field. Even if Rifampicine can be administrated at normal dose. The others drugs must be adapted on their clearance and the underlying disease. The two patients presented psychiatrical symptoms motivating a reduction of isoniazide dose witch threshold toxicity is lowered by renal failure state. These observations must increase watchfulness on nephrologist of undeveloping countries, confronted with tuberculosis renewed out break.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Adolescent
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Adult
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Antitubercular Agents / administration & dosage
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Antitubercular Agents / adverse effects
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Antitubercular Agents / pharmacokinetics
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Antitubercular Agents / therapeutic use
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Drug Therapy, Combination / administration & dosage
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Drug Therapy, Combination / therapeutic use
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Ethambutol / administration & dosage
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Ethambutol / therapeutic use
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Hallucinations / chemically induced
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Humans
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Isoniazid / administration & dosage
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Isoniazid / adverse effects
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Isoniazid / pharmacokinetics
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Isoniazid / therapeutic use
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Kidney Failure, Chronic / complications*
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Kidney Failure, Chronic / metabolism
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Kidney Failure, Chronic / therapy
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Male
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Metabolic Clearance Rate
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Renal Dialysis*
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Rifampin / administration & dosage
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Rifampin / therapeutic use
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Senegal / epidemiology
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Streptomycin / administration & dosage
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Streptomycin / therapeutic use
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Tuberculosis / complications*
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Tuberculosis / drug therapy
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Tuberculosis / epidemiology
Substances
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Antitubercular Agents
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Ethambutol
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Isoniazid
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Rifampin
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Streptomycin