Reactivity and suitability of t-Boc-protected thiophosphotyrosine intermediate analogs for the solid or solution phase peptide synthesis

E K Kim; H Choi; E S Lee

doi:10.1007/BF02975297

Reactivity and suitability of t-Boc-protected thiophosphotyrosine intermediate analogs for the solid or solution phase peptide synthesis

Arch Pharm Res. 1998 Jun;21(3):330-7. doi: 10.1007/BF02975297.

Authors

E K Kim¹, H Choi, E S Lee

Affiliation

¹ College of Pharmacy, Yeungnam University, Kyongsan, Korea.

PMID: 9875453
DOI: 10.1007/BF02975297

Abstract

N-(tert-Butoxycarbonyl)-O-(dimethylthiophosphono)-L-tyrosine (6) and N-(tert-butoxycarbony)-O-(dicyanoethylthiophosphono)-L-tyros ine (15) were prepared as intermediates for the synthesis of thiophosphotyrosine-containing peptides. The reactivity and suitability of two compounds for the solid phase or solution phase peptide synthesis utilizing t-Boc chemistry were examined.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Indicators and Reagents
Organophosphorus Compounds / chemical synthesis*
Organophosphorus Compounds / pharmacology
Peptides / chemical synthesis*
Tyrosine / analogs & derivatives*
Tyrosine / chemical synthesis
Tyrosine / pharmacology

Substances

Indicators and Reagents
Organophosphorus Compounds
Peptides
Tyrosine