Abstract
Fentanyl of a potent anilidopiperidine analgesic has been synthesized from a simple phenylethylamine by four step sequence. The key part of this synthesis involves an efficient construction of phenylethylpiperidone skeleton via aminomethano desilyltion-cyclization followed by Swern oxidation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analgesics, Opioid / chemical synthesis*
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Cyclization
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Fentanyl / chemical synthesis*
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Indicators and Reagents
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Oxidation-Reduction
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Piperidines / chemistry
Substances
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Analgesics, Opioid
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Indicators and Reagents
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Piperidines
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Fentanyl