Salivary defence factor concentrations in relation to oral and general parameters in HIV positive patients

Eur J Oral Sci. 1998 Dec;106(6):979-85. doi: 10.1046/j.0909-8836.1998.eos106601.x.

Abstract

The objective of this study was to determine the relationships between saliva protein concentrations, oral mucosal lesions, and systemic parameters in HIV positive patients and controls. Twenty-three control volunteers and 58 HIV-antibody positive patients received a complete oral examination and medical evaluation. In saliva and serum samples, protein concentrations were recorded by a nephelometric method. The systemic parameters assessed were CD4+ cell count, CDC stages and antiretroviral therapy. Oral mucosal lesion prevalence was higher among subjects with lower CD4+ counts. Considering the protein profile, correlations were recorded between saliva and serum protein concentration for IgA, haptoglobin and alpha1-proteinase inhibitor. Using assays of immune and non-immune saliva defence factors, we found that the evolution of cellular immuno-suppression during HIV infection was correlated to oral mucosal disease, showing a relationship between local and general systems.

MeSH terms

  • Adult
  • Albumins / analysis
  • Blood Proteins / analysis
  • CD4 Lymphocyte Count
  • Candidiasis, Oral / blood
  • Candidiasis, Oral / complications
  • Candidiasis, Oral / immunology
  • Case-Control Studies
  • Complement C3 / analysis
  • Female
  • HIV Seropositivity / blood
  • HIV Seropositivity / complications
  • HIV Seropositivity / immunology*
  • Haptoglobins / analysis
  • Humans
  • Immunity, Cellular
  • Immunity, Mucosal
  • Immunoglobulin Isotypes / analysis
  • Immunoglobulin Isotypes / blood
  • Leukoplakia, Hairy / blood
  • Leukoplakia, Hairy / complications
  • Leukoplakia, Hairy / immunology
  • Male
  • Middle Aged
  • Mouth Mucosa / pathology
  • Nephelometry and Turbidimetry
  • Orosomucoid / analysis
  • Periodontitis / blood
  • Periodontitis / complications
  • Periodontitis / immunology
  • Salivary Proteins and Peptides / analysis*
  • Salivary Proteins and Peptides / immunology*
  • Statistics, Nonparametric
  • Transferrin / analysis
  • alpha 1-Antitrypsin / analysis
  • alpha-Macroglobulins / analysis

Substances

  • Albumins
  • Blood Proteins
  • Complement C3
  • Haptoglobins
  • Immunoglobulin Isotypes
  • Orosomucoid
  • Salivary Proteins and Peptides
  • Transferrin
  • alpha 1-Antitrypsin
  • alpha-Macroglobulins