Abstract
Immunoglobulin G (IgG) responses require major histocompatibility complex (MHC)-restricted recognition of peptide fragments by conventional CD4(+) helper T cells. Immunoglobulin G responses to glycosylphosphatidylinositol (GPI)- anchored protein antigens, however, were found to be regulated in part through CD1d-restricted recognition of the GPI moiety by thymus-dependent, interleukin-4-producing CD4(+), natural killer cell antigen 1.1 [(NK1.1)+] helper T cells. The CD1-NKT cell pathway regulated immunogobulin G responses to the GPI-anchored surface antigens of Plasmodium and Trypanosoma and may be a general mechanism for rapid, MHC-unrestricted antibody responses to diverse pathogens.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antigen Presentation
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Antigen-Presenting Cells / immunology
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Antigens / analysis
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Antigens, CD1 / immunology*
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Antigens, Ly
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Antigens, Protozoan / immunology*
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Antigens, Surface
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Cells, Cultured
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Glycosylphosphatidylinositols / immunology*
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Immunoglobulin G / biosynthesis*
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Interleukin-4 / biosynthesis
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Lectins, C-Type
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Leishmania mexicana / immunology
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Major Histocompatibility Complex
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Mice
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Mice, Inbred Strains
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NK Cell Lectin-Like Receptor Subfamily B
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Plasmodium / immunology
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Proteins / analysis
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Protozoan Proteins / immunology
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T-Lymphocyte Subsets / immunology*
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T-Lymphocytes, Helper-Inducer / immunology*
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Trypanosoma brucei brucei / immunology
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Variant Surface Glycoproteins, Trypanosoma / immunology
Substances
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Antigens
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Antigens, CD1
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Antigens, Ly
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Antigens, Protozoan
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Antigens, Surface
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Glycosylphosphatidylinositols
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Immunoglobulin G
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Klrb1c protein, mouse
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Lectins, C-Type
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NK Cell Lectin-Like Receptor Subfamily B
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Proteins
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Protozoan Proteins
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Variant Surface Glycoproteins, Trypanosoma
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circumsporozoite protein, Protozoan
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Interleukin-4