The importance of cerebrospinal fluid lactate in the evaluation of congenital lactic acidosis

J Pediatr. 1999 Jan;134(1):99-102. doi: 10.1016/s0022-3476(99)70379-3.

Abstract

In 27 of 28 children with congenital lactic acidosis, cerebrospinal fluid lactate was higher than venous blood lactate. The mean +/- SEM difference between these variables was 2.4 +/- 0.3 mmol/L (P =.0001). Girls or patients with pyruvate dehydrogenase deficiency had higher cerebrospinal fluid lactate concentrations than boys or patients with respiratory chain defects or mitochondrial DNA mutations.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acidosis, Lactic / cerebrospinal fluid*
  • Acidosis, Lactic / congenital*
  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • DNA, Mitochondrial / genetics
  • Electron Transport
  • Female
  • Humans
  • Infant
  • Lactates / blood
  • Lactates / cerebrospinal fluid*
  • Male
  • Mutation
  • Pyruvate Dehydrogenase Complex Deficiency Disease / cerebrospinal fluid
  • Pyruvate Dehydrogenase Complex Deficiency Disease / metabolism*

Substances

  • DNA, Mitochondrial
  • Lactates