Abstract
Extensive molecular modelling studies, including conformational analysis and the comparison of molecular electrostatic potential distributions, wee used to evaluate structural parameters of new antagonists containing acyclic replacements of the N = C-N imidazole region. The synthesis and the biological screening of a series of acyl biphenyltetrazole derivatives were planned and realized to gain an insight into the structure-activity relationships of this unusual class of Angiotensin II antagonists.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Angiotensin Receptor Antagonists*
-
Antihypertensive Agents / chemistry
-
Biphenyl Compounds / chemical synthesis
-
Biphenyl Compounds / chemistry*
-
Biphenyl Compounds / pharmacology
-
Drug Design
-
Humans
-
Imidazoles / chemical synthesis
-
Imidazoles / chemistry*
-
Imidazoles / pharmacology
-
Kinetics
-
Losartan / chemistry
-
Models, Molecular
-
Molecular Conformation
-
Molecular Structure
-
Static Electricity
-
Stereoisomerism
-
Structure-Activity Relationship
-
Tetrazoles / chemical synthesis
-
Tetrazoles / chemistry*
-
Tetrazoles / pharmacology
-
Valine / analogs & derivatives
-
Valine / chemistry
-
Valsartan
Substances
-
Angiotensin Receptor Antagonists
-
Antihypertensive Agents
-
Biphenyl Compounds
-
Imidazoles
-
Tetrazoles
-
Valsartan
-
Valine
-
Losartan