Abstract
Long-range, directed migration is particularly dramatic in the cerebral cortex, where postmitotic neurons generated deep in the brain migrate to form layers with distinct form and function. In the X-linked dominant human disorder periventricular heterotopia (PH), many neurons fail to migrate and persist as nodules lining the ventricular surface. Females with PH present with epilepsy and other signs, including patent ductus arteriosus and coagulopathy, while hemizygous males die embryonically. We have identified the PH gene as filamin 1 (FLN1), which encodes an actin-cross-linking phosphoprotein that transduces ligand-receptor binding into actin reorganization, and which is required for locomotion of many cell types. FLN1 shows previously unrecognized, high-level expression in the developing cortex, is required for neuronal migration to the cortex, and is essential for embryogenesis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Abnormalities, Multiple / genetics*
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Aging
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Animals
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Brain / abnormalities
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Brain / anatomy & histology
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Brain / pathology*
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Brain Diseases / genetics*
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Brain Diseases / pathology
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Brain Diseases / physiopathology
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Cerebral Cortex / abnormalities
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Cerebral Cortex / pathology
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Cerebral Cortex / physiopathology*
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Cerebral Ventricles* / abnormalities
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Cerebral Ventricles* / pathology
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Choristoma / genetics*
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Choristoma / physiopathology
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Chromosome Mapping
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Contractile Proteins / genetics*
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Embryonic and Fetal Development
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Epilepsy / genetics
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Female
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Fetal Death
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Filamins
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Gene Expression Regulation, Developmental
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Humans
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Magnetic Resonance Imaging
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Male
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Mice
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Microfilament Proteins / genetics*
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Neurons / pathology
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Neurons / physiology*
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Pedigree
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Phenotype
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Sex Characteristics
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X Chromosome
Substances
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Contractile Proteins
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FLNA protein, human
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Filamins
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Microfilament Proteins