Abstract
The recent structure determinations of the mammalian effector enzyme adenylyl cyclase reveal the structure of its catalytic core, provide new insights into its catalytic mechanism and suggest how diverse signaling molecules regulate its activity.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adenylyl Cyclases / chemistry
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Adenylyl Cyclases / metabolism*
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Animals
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Binding Sites
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Calcium-Calmodulin-Dependent Protein Kinase Type 2
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Calcium-Calmodulin-Dependent Protein Kinases / metabolism
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Catalysis
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Colforsin / pharmacology
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GTP-Binding Proteins / metabolism
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Metals / metabolism
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Models, Molecular
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Protein Conformation
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Protein Kinase C / metabolism
Substances
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Metals
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Colforsin
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Protein Kinase C
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Calcium-Calmodulin-Dependent Protein Kinase Type 2
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Calcium-Calmodulin-Dependent Protein Kinases
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GTP-Binding Proteins
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Adenylyl Cyclases