Novel glycoinositolphosphosphingolipids, basidiolipids, from Agaricus

Eur J Biochem. 1999 Jan;259(1-2):331-8. doi: 10.1046/j.1432-1327.1999.00040.x.

Abstract

From the edible mushroom, the basidiomycetes Agaricus bisporus and Agaricus campestris, a novel carbohydrate-homologous series of four glyco-inositol-phospho-sphingolipids, designated basidiolipids, was isolated and the constituents purified. The chemical structures of the basidiolipids were elucidated to be: Manpbeta1-2inositol1-phospho-ceramide, Galpalpha-6[Fucpalpha-2]Galpbeta-6Manpbeta-2i nositol1-phospho-ceramide, Galpalpha-6Galpalpha-6[Fucpalpha-2]Galpbeta- 6Manpbeta-2inositol1-phospho-ceramide and Galpalpha-6Galpalpha-6Galpalpha-6[Fucpalpha-2] Galpbeta-6Manpbeta-2ino sitol1-phospho-ceramide. All four glycolipids contained a ceramide which was composed of phytosphingosine and predominantly alpha-hydroxy-behenic and alpha-hydroxy-lignoceric acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / chemistry
  • Agaricus / chemistry*
  • Carbohydrate Sequence
  • Ceramides / chemistry*
  • Fatty Acids / chemistry
  • Hydroxy Acids / chemistry
  • Inositol Phosphates / isolation & purification*
  • Molecular Sequence Data
  • Nuclear Magnetic Resonance, Biomolecular
  • Phospholipids / chemistry*
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Sphingosine / analogs & derivatives*
  • Sphingosine / isolation & purification

Substances

  • Adjuvants, Immunologic
  • Ceramides
  • Fatty Acids
  • Hydroxy Acids
  • Inositol Phosphates
  • Phospholipids
  • inositol 1-phosphate
  • phytosphingosine
  • behenic acid
  • Sphingosine
  • lignoceric acid