[Survival and pulmonary hemodynamics in patients with sequelae of pulmonary tuberculosis who received antituberculosis chemotherapy and home oxygen therapy]

Nihon Kokyuki Gakkai Zasshi. 1998 Nov;36(11):934-8.
[Article in Japanese]

Abstract

To date, the pulmonary hemodynamics of patients with sequelae of pulmonary tuberculosis have usually been examined as a unified set of criteria regardless of the treatments that patients undergo. Attracted by this subject, we studied the cerrelations between survival and pulmonary hemodynamics in patients with sequelae of pulmonary tuberculosis who were treated with antituberculosis drugs and home oxygen therapy (HOT). Our study examined 21 patients with a mean ages of 58.0 years, mean PaO2 of 59.3 +/- 11.4 mm Hg, and mean PaCO2 of 51.9 +/- 6.3 mm Hg. In pulmonary function tests, mean % VC was 44.1 +/- 16.3%, and mean FEV 1%, 66.6 +/- 23.0%. Twenty of the patients were given a diagnosis of pulmonary hypertension. Eighteen of the patients received HOT; as a group, their 3-year survival rate was 62.6%, which was not statistically significant compared to survival observed in post Japanese studies. Among the HOT patients, blood gases and pulmonary hemodynamics did not vary significantly between those who died within 2 years after right heart catheterization (short-term survivors) and those who lived for more than 5 years (long-term survivors). However, VC, % VC, and FVC values were significantly lower in the short-term survivors than in the long-term survivors. In conclusion, these findings revealed no statistically significant, differences compared with the data from past studies. Although pulmonary hypertension is associated with the poor prognosis for chronic obstructive pulmonary tuberculosis patients, in the patients we studied, the principle prognostic determinant was the seriousness of the restrictive ventilatory impairment, not pulmonary hypertension.

Publication types

  • English Abstract

MeSH terms

  • Aged
  • Antitubercular Agents / therapeutic use*
  • Female
  • Hemodynamics
  • Humans
  • Hypertension, Pulmonary / complications
  • Male
  • Middle Aged
  • Oxygen Inhalation Therapy*
  • Prognosis
  • Pulmonary Circulation*
  • Self Care
  • Survivors
  • Tuberculosis, Pulmonary / physiopathology*
  • Tuberculosis, Pulmonary / therapy

Substances

  • Antitubercular Agents