Abstract
Ten acetylenic enol ethers of glycerols, including six new compounds (1-6) and a linear acetylenic alcohol (7), have been isolated from a sponge of the genus Petrosia. The structures of the novel compounds were elucidated by spectroscopic methods. The absolute stereochemistry of 1-7 was determined by chemical transformations and the Mosher method. Some of these compounds exhibited weak cytotoxicity against a human leukemia cell-line (K-562).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylene / chemistry
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Drug Screening Assays, Antitumor
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Ethers
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Glycerol / chemistry
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Glycerol / isolation & purification*
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Glycerol / pharmacology
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Humans
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K562 Cells
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Structure
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Porifera / chemistry*
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Stereoisomerism
Substances
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Antineoplastic Agents
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Ethers
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Acetylene
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Glycerol