Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella

J Nat Prod. 1999 Jan;62(1):173-5. doi: 10.1021/np980293y.

Abstract

Discorhabdin P (1), a new discorhabdin analogue, has been isolated from a deep-water marine sponge of the genus Batzella. Discorhabdin P (1) inhibited the phosphatase activity of calcineurin and the peptidase activity of CPP32. It also showed in vitro cytotoxicity against P-388 and A-549 cell lines. The isolation and structure elucidation of discorhabdin P (1) are described.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Calcineurin Inhibitors
  • Caspase 3
  • Caspase Inhibitors
  • Crystallography, X-Ray
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Structure
  • Porifera / chemistry*
  • Quinones / chemistry
  • Quinones / isolation & purification*
  • Quinones / pharmacology
  • Spectrometry, Mass, Fast Atom Bombardment
  • Spiro Compounds / chemistry
  • Spiro Compounds / isolation & purification*
  • Spiro Compounds / pharmacology
  • Thiazepines*
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Calcineurin Inhibitors
  • Caspase Inhibitors
  • Enzyme Inhibitors
  • Quinones
  • Spiro Compounds
  • Thiazepines
  • discorhabdin P
  • CASP3 protein, human
  • Casp3 protein, mouse
  • Caspase 3