Abstract
Anti-GQ1b antibodies were assayed by an enzyme-linked immunosorbent assay in sera from patients with non-neurological disorders (N = 20), and with various neurological disorders (N = 59), including nine cases of Miller Fisher syndrome, 16 cases of Guillain-Barré syndrome and one case of acute post-infectious ophthalmoparesis. Such antibodies were found in most cases (8 out of 9) of Miller Fisher syndrome, and at very high titres, in one case of Guillain-Barré syndrome characterised by an initial ophthalmoparesis, and in the case of isolated post-infectious ophthalmoparesis. The latter was characterised by a long-lasting occurrence of these antibodies. Anti-GQ1b antibodies are specific for an immune-mediated neuropathy of the cranial, especially oculomotor, nerves.
MeSH terms
-
Autoantibodies / blood
-
Autoantibodies / immunology*
-
Autoantigens / immunology*
-
Autoimmune Diseases / etiology
-
Autoimmune Diseases / immunology*
-
Campylobacter Infections / complications
-
Campylobacter Infections / immunology
-
Campylobacter jejuni
-
Enzyme-Linked Immunosorbent Assay
-
Female
-
Gangliosides / immunology*
-
Humans
-
Immunoglobulin G / blood
-
Immunoglobulin G / immunology
-
Immunoglobulin M / blood
-
Immunoglobulin M / immunology
-
Male
-
Middle Aged
-
Miller Fisher Syndrome / etiology
-
Miller Fisher Syndrome / immunology*
-
Nervous System Diseases / immunology
-
Ophthalmoplegia / etiology
-
Ophthalmoplegia / immunology
-
Polyradiculoneuropathy / etiology
-
Polyradiculoneuropathy / immunology*
-
Virus Diseases / complications
-
Virus Diseases / immunology
Substances
-
Autoantibodies
-
Autoantigens
-
Gangliosides
-
Immunoglobulin G
-
Immunoglobulin M
-
GQ1b ganglioside