Abstract
Prostatitis due to vancomycin-resistant enterococci has not been previously described. Reported here is a case of chronic prostatitis due to Enterococcus faecium, resistant to vancomycin, ampicillin, ciprofloxacin and doxycycline, in a 42-year-old liver transplant recipient. Treatment with a combination of rifampin and nitrofurantoin for 6 weeks resulted in long-lasting cure. Other antimicrobial agents active in vitro against vancomycin-resistant enterococci, such as quinupristin/ dalfopristin and chloramphenicol, are unlikely to achieve sufficient prostatic tissue levels to be successfully utilized for treatment of this condition.
MeSH terms
-
Adult
-
Anti-Bacterial Agents / pharmacology
-
Anti-Bacterial Agents / therapeutic use
-
Anti-Infective Agents, Urinary / therapeutic use
-
Chronic Disease
-
Drug Resistance, Microbial
-
Drug Resistance, Multiple
-
Drug Therapy, Combination
-
Enterococcus faecium / drug effects*
-
Enterococcus faecium / isolation & purification
-
Gram-Positive Bacterial Infections / drug therapy*
-
Gram-Positive Bacterial Infections / microbiology
-
Humans
-
Liver Transplantation / adverse effects
-
Male
-
Nitrofurantoin / therapeutic use*
-
Prostatitis / drug therapy*
-
Prostatitis / microbiology
-
Rifampin / therapeutic use*
-
Urine / microbiology
-
Vancomycin / pharmacology*
Substances
-
Anti-Bacterial Agents
-
Anti-Infective Agents, Urinary
-
Vancomycin
-
Nitrofurantoin
-
Rifampin