Gastroschisis is an abdominal wall defect found in the newborn that requires immediate interventions in the delivery room. To provide appropriate management, clinicians must have a clear understanding of the etiology and pathophysiology of gastroschisis. Stabilization in the delivery room is important and begins with establishing an airway, preventing hypothermia, and protecting the exposed bowel from the environment. Surgical treatment is required in the early neonatal period. Adequate preparation prior to repair is essential to ensure optimal outcomes.