Abstract
The tumour-necrosis-factor-family molecule osteoprotegerin ligand (OPGL; also known as TRANCE, RANKL and ODF) has been identified as a potential osteoclast differentiation factor and regulator of interactions between T cells and dendritic cells in vitro. Mice with a disrupted opgl gene show severe osteopetrosis and a defect in tooth eruption, and completely lack osteoclasts as a result of an inability of osteoblasts to support osteoclastogenesis. Although dendritic cells appear normal, opgl-deficient mice exhibit defects in early differentiation of T and B lymphocytes. Surprisingly, opgl-deficient mice lack all lymph nodes but have normal splenic structure and Peyer's patches. Thus OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo.
MeSH terms
-
Animals
-
B-Lymphocytes / cytology
-
Bone Remodeling / physiology
-
Carrier Proteins*
-
Cell Differentiation / physiology
-
Cells, Cultured
-
Cytokines / biosynthesis
-
Cytokines / genetics
-
Cytokines / physiology*
-
Dendritic Cells / cytology
-
Embryonic and Fetal Development / physiology*
-
Female
-
Gene Targeting
-
Growth Substances / genetics
-
Growth Substances / physiology*
-
Hematopoiesis, Extramedullary
-
Hematopoietic Stem Cells / cytology
-
Leukopoiesis / physiology
-
Lymph Nodes / abnormalities
-
Lymph Nodes / embryology*
-
Lymphocyte Activation
-
Lymphocytes / cytology*
-
Lymphocytes / immunology
-
Male
-
Membrane Glycoproteins*
-
Mice
-
Mice, Inbred BALB C
-
Mice, Inbred C57BL
-
Molecular Sequence Data
-
Mutagenesis
-
Osteoclasts / cytology*
-
Osteogenesis / physiology*
-
Osteopetrosis / genetics
-
RANK Ligand
-
Receptor Activator of Nuclear Factor-kappa B
-
T-Lymphocytes / cytology
-
T-Lymphocytes / immunology
-
Thymus Gland / cytology
-
Thymus Gland / embryology
Substances
-
Carrier Proteins
-
Cytokines
-
Growth Substances
-
Membrane Glycoproteins
-
RANK Ligand
-
Receptor Activator of Nuclear Factor-kappa B
-
Tnfrsf11a protein, mouse
-
Tnfsf11 protein, mouse