The purpose of this research was to determine the influence of dental amalgam on the blood count of the holder of amalgam fillings. The experiments were performed on 30 Wistar rats. One group of rats received 8 mg of fragmented dental amalgam daily incorporated in their food during 60 days (group S2) and group S3 received amalgam fillings in their anterior teeth, which remained for 60 days. Both experiment groups (S2 and S3) were compared to one another as well as to control group (S1). From all animals of all experiment groups blood samples were drawn during the experiment in particular periods and complete blood count and differential blood count was performed. The findings of particular indicators of the complete blood count and differential blood count of all experiment rats groups S1, S2 and S3 do not deviate from the physiological values regarding age and sex of the observed animals.