Jumping translocation of homogeneously staining region and tetraploidy with double minutes in acute myelomonocytic leukemia

Cancer Genet Cytogenet. 1999 Feb;109(1):40-4. doi: 10.1016/s0165-4608(98)00144-7.

Abstract

We report a 71-year-old patient with acute myelomonocytic leukemia (AMMoL) who had complicated chromosomal abnormalities showing diploidy with a jumping translocation of a homogeneously staining region (hsr) and tetraploidy with double minutes (dmin). The analysis of gene amplification showed that hsr and dmin were the results of C-ETS 1 gene amplification. After induction chemotherapy, tetraploidy with dmin completely disappeared, while diploidy with hsr and del(11)(q23) remained until the patient died. It is speculated that hsr is more stable than dmin during chemotherapy and that the presence of tetraploidy is not necessarily a factor of poor response to chemotherapy for acute leukemia.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Chromosome Mapping
  • Chromosomes, Human, Pair 11*
  • Cytarabine / administration & dosage
  • Daunorubicin / administration & dosage
  • Fatal Outcome
  • Female
  • Gene Amplification
  • Humans
  • Karyotyping
  • Leukemia, Myelomonocytic, Acute / drug therapy
  • Leukemia, Myelomonocytic, Acute / genetics*
  • Leukemia, Myelomonocytic, Acute / pathology
  • Metaphase
  • Polyploidy*
  • Prednisone / administration & dosage
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins c-ets
  • Proto-Oncogenes*
  • Transcription Factors / genetics*
  • Translocation, Genetic*

Substances

  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-ets
  • Transcription Factors
  • Cytarabine
  • Prednisone
  • Daunorubicin