Daigle DM - Search Results

1

Prodigious substrate specificity of AAC(6')-APH(2"), an aminoglycoside antibiotic resistance determinant in enterococci and staphylococci.

Daigle DM, Hughes DW, Wright GD. Daigle DM, et al. Chem Biol. 1999 Feb;6(2):99-110. doi: 10.1016/S1074-5521(99)80006-4. Chem Biol. 1999. PMID: 10021417

2

Domain-domain interactions in the aminoglycoside antibiotic resistance enzyme AAC(6')-APH(2'').

Boehr DD, Daigle DM, Wright GD. Boehr DD, et al. Among authors: daigle dm. Biochemistry. 2004 Aug 3;43(30):9846-55. doi: 10.1021/bi049135y. Biochemistry. 2004. PMID: 15274639

3

Multicopy suppressors for novel antibacterial compounds reveal targets and drug efflux susceptibility.

Li X, Zolli-Juran M, Cechetto JD, Daigle DM, Wright GD, Brown ED. Li X, et al. Among authors: daigle dm. Chem Biol. 2004 Oct;11(10):1423-30. doi: 10.1016/j.chembiol.2004.08.014. Chem Biol. 2004. PMID: 15489169

4

Inhibition of aminoglycoside antibiotic resistance enzymes by protein kinase inhibitors.

Daigle DM, McKay GA, Wright GD. Daigle DM, et al. J Biol Chem. 1997 Oct 3;272(40):24755-8. doi: 10.1074/jbc.272.40.24755. J Biol Chem. 1997. PMID: 9312069 Free article.

5

Aminoglycoside antibiotic phosphotransferases are also serine protein kinases.

Daigle DM, McKay GA, Thompson PR, Wright GD. Daigle DM, et al. Chem Biol. 1999 Jan;6(1):11-8. doi: 10.1016/S1074-5521(99)80016-7. Chem Biol. 1999. PMID: 9889150

6

A 2.13 A structure of E. coli dihydrofolate reductase bound to a novel competitive inhibitor reveals a new binding surface involving the M20 loop region.

Summerfield RL, Daigle DM, Mayer S, Mallik D, Hughes DW, Jackson SG, Sulek M, Organ MG, Brown ED, Junop MS. Summerfield RL, et al. Among authors: daigle dm. J Med Chem. 2006 Nov 30;49(24):6977-86. doi: 10.1021/jm060570v. J Med Chem. 2006. PMID: 17125251

7

Characterization of the Bacillus subtilis GTPase YloQ and its role in ribosome function.

Campbell TL, Daigle DM, Brown ED. Campbell TL, et al. Among authors: daigle dm. Biochem J. 2005 Aug 1;389(Pt 3):843-52. doi: 10.1042/BJ20041873. Biochem J. 2005. PMID: 15828870 Free PMC article.

8

High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate.

Zolli-Juran M, Cechetto JD, Hartlen R, Daigle DM, Brown ED. Zolli-Juran M, et al. Among authors: daigle dm. Bioorg Med Chem Lett. 2003 Aug 4;13(15):2493-6. doi: 10.1016/s0960-894x(03)00480-3. Bioorg Med Chem Lett. 2003. PMID: 12852950

9

YjeQ, an essential, conserved, uncharacterized protein from Escherichia coli, is an unusual GTPase with circularly permuted G-motifs and marked burst kinetics.

Daigle DM, Rossi L, Berghuis AM, Aravind L, Koonin EV, Brown ED. Daigle DM, et al. Biochemistry. 2002 Sep 17;41(37):11109-17. doi: 10.1021/bi020355q. Biochemistry. 2002. PMID: 12220175

10

An expedient and facile one-step synthesis of a biguanide library by microwave irradiation coupled with simple product filtration. Inhibitors of dihydrofolate reductase.

Mayer S, Daigle DM, Brown ED, Khatri J, Organ MG. Mayer S, et al. Among authors: daigle dm. J Comb Chem. 2004 Sep-Oct;6(5):776-82. doi: 10.1021/cc049953+. J Comb Chem. 2004. PMID: 15360213

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