Matsuda A - Search Results

1

Open channel block of NMDA receptors by conformationally restricted analogs of milnacipran and their protective effect against NMDA-induced neurotoxicity.

Noguchi T, Ishii K, Ohtubo Y, Shuto S, Ono S, Matsuda A, Yoshii K. Noguchi T, et al. Among authors: matsuda a. Synapse. 1999 Feb;31(2):87-96. doi: 10.1002/(SICI)1098-2396(199902)31:2<87::AID-SYN1>3.0.CO;2-H. Synapse. 1999. PMID: 10024005

2

Synthesis and biological activity of conformationally restricted analogs of milnacipran: (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxami de, an efficient noncompetitive N-methyl-D-aspartic acid receptor antagonist.

Shuto S, Ono S, Hase Y, Ueno Y, Noguchi T, Yoshii K, Matsuda A. Shuto S, et al. Among authors: matsuda a. J Med Chem. 1996 Nov 22;39(24):4844-52. doi: 10.1021/jm960495w. J Med Chem. 1996. PMID: 8941398

3

Synthesis and biological activity of conformationally restricted analogues of milnacipran: (1S, 2R)-1-phenyl-2-[(R)-1-amino-2-propynyl]-N,N- diethylcyclopropanecarboxamide is a novel class of NMDA receptor channel blocker.

Shuto S, Ono S, Imoto H, Yoshii K, Matsuda A. Shuto S, et al. Among authors: matsuda a. J Med Chem. 1998 Aug 27;41(18):3507-14. doi: 10.1021/jm980238m. J Med Chem. 1998. PMID: 9719604

4

Conformational analysis of the NMDA receptor antagonist (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide (PPDC) designed by a novel conformational restriction method based on the structural feature of cyclopropane ring.

Ono S, Ogawa K, Yamashita K, Yamamoto T, Kazuta Y, Matsuda A, Shuto S. Ono S, et al. Among authors: matsuda a. Chem Pharm Bull (Tokyo). 2002 Jul;50(7):966-8. doi: 10.1248/cpb.50.966. Chem Pharm Bull (Tokyo). 2002. PMID: 12130856 Free article.

5

(+/-)-(Z)-2-(aminomethyl)-1-phenylcyclopropanecarboxamide derivatives as a new prototype of NMDA receptor antagonists.

Shuto S, Takada H, Mochizuki D, Tsujita R, Hase Y, Ono S, Shibuya N, Matsuda A. Shuto S, et al. Among authors: matsuda a. J Med Chem. 1995 Jul 21;38(15):2964-8. doi: 10.1021/jm00015a019. J Med Chem. 1995. PMID: 7636857

6

(1S,2R)-1-Phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide (PPDC), a new class of NMDA-receptor antagonist: molecular design by a novel conformational restriction strategy.

Shuto S, Yoshii K, Matsuda A. Shuto S, et al. Among authors: matsuda a. Jpn J Pharmacol. 2001 Mar;85(3):207-13. doi: 10.1254/jjp.85.207. Jpn J Pharmacol. 2001. PMID: 11325012 Free article. Review.

7

A method for designing conformationally restricted analogues based on allylic strain: synthesis of a novel class of noncompetitive NMDA receptor antagonists having the acrylamide structure.

Ohmori Y, Yamashita A, Tsujita R, Yamamoto T, Taniuchi K, Matsuda A, Shuto S. Ohmori Y, et al. Among authors: matsuda a. J Med Chem. 2003 Dec 4;46(25):5326-33. doi: 10.1021/jm030226n. J Med Chem. 2003. PMID: 14640541

8

Synthesis of conformationally restricted analogs of baclofen, a potent GABAB receptor agonist, by the introduction of a cyclopropane ring.

Shuto S, Shibuya N, Yamada S, Ohkura T, Kimura R, Matsuda A. Shuto S, et al. Among authors: matsuda a. Chem Pharm Bull (Tokyo). 1999 Aug;47(8):1188-92. doi: 10.1248/cpb.47.1188. Chem Pharm Bull (Tokyo). 1999. PMID: 10478475

9

Development of versatile cis- and trans-dicarbon-substituted chiral cyclopropane units: synthesis of (1S,2R)- and (1R,2R)-2-aminomethyl-1-(1H-imidazol-4-yl)cyclopropanes and their enantiomers as conformationally restricted analogues of histamine.

Kazuta Y, Matsuda A, Shuto S. Kazuta Y, et al. Among authors: matsuda a. J Org Chem. 2002 Mar 8;67(5):1669-77. doi: 10.1021/jo010852x. J Org Chem. 2002. PMID: 11871901

10

Synthesis of (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide (PPDC) derivatives modified at the carbamoyl moiety as a new class of NMDA receptor antagonists.

Kazuta Y, Tsujita R, Ogawa K, Hokonohara T, Yamashita K, Morino K, Matsuda A, Shuto S. Kazuta Y, et al. Among authors: matsuda a. Bioorg Med Chem. 2002 Jun;10(6):1777-91. doi: 10.1016/s0968-0896(02)00030-5. Bioorg Med Chem. 2002. PMID: 11937336

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