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Molecular chemotherapy for breast cancer.
Patterson A, Harris AL. Patterson A, et al. Drugs Aging. 1999 Feb;14(2):75-90. doi: 10.2165/00002512-199914020-00001. Drugs Aging. 1999. PMID: 10084362 Review.
Does reductive metabolism predict response to tirapazamine (SR 4233) in human non-small-cell lung cancer cell lines?
Chinje EC, Patterson AV, Saunders MP, Lockyer SD, Harris AL, Stratford IJ. Chinje EC, et al. Among authors: patterson av. Br J Cancer. 1999 Dec;81(7):1127-33. doi: 10.1038/sj.bjc.6690819. Br J Cancer. 1999. PMID: 10584872 Free PMC article.
The bioreductive drug tirapazamine (TPZ, SR 4233, WIN 59075) is a lead compound in a series of potent cytotoxins that selectively kill hypoxic rodent and human solid tumour cells in vitro and in vivo. ...Our results demonstrate that P450R plays a significant …
The bioreductive drug tirapazamine (TPZ, SR 4233, WIN 59075) is a lead compound in a series of potent cytotoxins that selectiv …
The relative importance of NADPH: cytochrome c (P450) reductase for determining the sensitivity of human tumour cells to the indolequinone EO9 and related analogues lacking functionality at the C-2 and C-3 positions.
Saunders MP, Jaffar M, Patterson AV, Nolan J, Naylor MA, Phillips RM, Harris AL, Stratford IJ. Saunders MP, et al. Among authors: patterson av. Biochem Pharmacol. 2000 Apr 15;59(8):993-6. doi: 10.1016/s0006-2952(99)00405-0. Biochem Pharmacol. 2000. PMID: 10692564
Targeting gene expression to hypoxic tumor cells.
Dachs GU, Patterson AV, Firth JD, Ratcliffe PJ, Townsend KM, Stratford IJ, Harris AL. Dachs GU, et al. Among authors: patterson av. Nat Med. 1997 May;3(5):515-20. doi: 10.1038/nm0597-515. Nat Med. 1997. PMID: 9142119
Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069.
Patterson AV, Saunders MP, Chinje EC, Talbot DC, Harris AL, Strafford IJ. Patterson AV, et al. Br J Cancer. 1997;76(10):1338-47. doi: 10.1038/bjc.1997.558. Br J Cancer. 1997. PMID: 9374381 Free PMC article.
P450 reductase (NADPH: cytochrome c (P450) reductase, EC 1.6.2.4) plays an important role in the reductive activation of the bioreductive drug tirapazamine (SR4233). Thus, in a panel of human breast cancer cell lines, expression of P450 reductase correlated with both the h …
P450 reductase (NADPH: cytochrome c (P450) reductase, EC 1.6.2.4) plays an important role in the reductive activation of the bioreductive dr …
Induction of thymidine phosphorylase as a pharmacodynamic end-point in patients with advanced carcinoma treated with 5-fluorouracil, folinic acid and interferon alpha.
Braybrooke JP, Propper DJ, O'Byrne KJ, Koukourakis MI, Patterson AV, Houlbrook S, Love SD, Varcoe S, Taylor M, Ganesan TS, Talbot DC, Harris AL. Braybrooke JP, et al. Among authors: patterson av. Br J Cancer. 2000 Jul;83(2):219-24. doi: 10.1054/bjoc.2000.1230. Br J Cancer. 2000. PMID: 10901374 Free PMC article. Clinical Trial.
1,647 results