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Rational design, conformational studies and bioactivity of highly potent conformationally constrained calcitonin analogues.
Kapurniotu A, Kayed R, Taylor JW, Voelter W. Kapurniotu A, et al. Eur J Biochem. 1999 Oct;265(2):606-18. doi: 10.1046/j.1432-1327.1999.00708.x. Eur J Biochem. 1999. PMID: 10504392 Free article.
Our studies on the conformational features of human calcitonin (hCt) bioactivity have led to the conformationally constrained hCt analogue cyclo17,21-[Asp17, Lys21]hCt (1), which had a 5-10 times higher in vivo hypocalcaemic potency than hCt [Kapurniotu, A. & …
Our studies on the conformational features of human calcitonin (hCt) bioactivity have led to the conformationally constrained hCt analogue c …
70 results