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Page 1
Pregabalin induces hepatic hypoxia and increases endothelial cell proliferation in mice, a process inhibited by dietary vitamin E supplementation.
Criswell KA, Cook JC, Morse D, Lawton M, Somps C, Obert L, Roy M, Sokolowski S, Koza-Taylor P, Colangelo J, Navetta K, Brady J, Pegg D, Wojcinski Z, Rahbari R, Duddy S, Anderson T. Criswell KA, et al. Toxicol Sci. 2012 Jul;128(1):42-56. doi: 10.1093/toxsci/kfs148. Epub 2012 Apr 26. Toxicol Sci. 2012. PMID: 22539613
Key components of the mode of action for hemangiosarcoma induction in pregabalin-treated mice: evidence of increased bicarbonate, dysregulated erythropoiesis, macrophage activation, and increased angiogenic growth factors in mice but not in rats.
Criswell KA, Wojcinski Z, Pegg D, Albassam M, Duddy S, Olsen E, Bailie M, Foote S, Anderson T. Criswell KA, et al. Toxicol Sci. 2012 Jul;128(1):22-41. doi: 10.1093/toxsci/kfs147. Epub 2012 Apr 26. Toxicol Sci. 2012. PMID: 22539625
Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606.
Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, Kim DY, Mobley WC, Rissman RA, Tanzi RE. Wagner SL, et al. Among authors: duddy sk. J Pharmacol Exp Ther. 2017 Jul;362(1):31-44. doi: 10.1124/jpet.117.240861. Epub 2017 Apr 17. J Pharmacol Exp Ther. 2017. PMID: 28416568 Free PMC article.
Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention.
Rynearson KD, Ponnusamy M, Prikhodko O, Xie Y, Zhang C, Nguyen P, Hug B, Sawa M, Becker A, Spencer B, Florio J, Mante M, Salehi B, Arias C, Galasko D, Head BP, Johnson G, Lin JH, Duddy SK, Rissman RA, Mobley WC, Thinakaran G, Tanzi RE, Wagner SL. Rynearson KD, et al. Among authors: duddy sk. J Exp Med. 2021 Apr 5;218(4):e20202560. doi: 10.1084/jem.20202560. J Exp Med. 2021. PMID: 33651103 Free PMC article.
Development of Clinically Viable Non-Muscle Myosin II Small Molecule Inhibitors with Broad Therapeutic Potential.
Radnai L, Young EJ, Kikuti C, Hafenbreidel M, Stremel RF, Lin L, Toth K, Pasetto P, Jin X, Patel A, Conlon M, Briggs S, Heidsieck L, Sweeney HL, Sellers J, Krieger-Burke T, Martin WH, Sisco J, Young S, Pearson P, Rumbaugh G, Araldi GL, Duddy SK, Cameron MD, Surman M, Houdusse A, Griffin PR, Kamenecka TM, Miller CA. Radnai L, et al. Among authors: duddy sk. bioRxiv [Preprint]. 2024 Oct 12:2024.10.07.617018. doi: 10.1101/2024.10.07.617018. bioRxiv. 2024. PMID: 39416074 Free PMC article. Preprint.
26 results