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Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma.
Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS, Devchand P, Wahli W, Willson TM, Lenhard JM, Lehmann JM. Kliewer SA, et al. Among authors: lehmann jm. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4318-23. doi: 10.1073/pnas.94.9.4318. Proc Natl Acad Sci U S A. 1997. PMID: 9113987 Free PMC article.
Bile acids: natural ligands for an orphan nuclear receptor.
Parks DJ, Blanchard SG, Bledsoe RK, Chandra G, Consler TG, Kliewer SA, Stimmel JB, Willson TM, Zavacki AM, Moore DD, Lehmann JM. Parks DJ, et al. Among authors: lehmann jm. Science. 1999 May 21;284(5418):1365-8. doi: 10.1126/science.284.5418.1365. Science. 1999. PMID: 10334993
A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation.
Oberfield JL, Collins JL, Holmes CP, Goreham DM, Cooper JP, Cobb JE, Lenhard JM, Hull-Ryde EA, Mohr CP, Blanchard SG, Parks DJ, Moore LB, Lehmann JM, Plunket K, Miller AB, Milburn MV, Kliewer SA, Willson TM. Oberfield JL, et al. Among authors: lehmann jm. Proc Natl Acad Sci U S A. 1999 May 25;96(11):6102-6. doi: 10.1073/pnas.96.11.6102. Proc Natl Acad Sci U S A. 1999. PMID: 10339548 Free PMC article.
A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat.
Brown KK, Henke BR, Blanchard SG, Cobb JE, Mook R, Kaldor I, Kliewer SA, Lehmann JM, Lenhard JM, Harrington WW, Novak PJ, Faison W, Binz JG, Hashim MA, Oliver WO, Brown HR, Parks DJ, Plunket KD, Tong WQ, Menius JA, Adkison K, Noble SA, Willson TM. Brown KK, et al. Among authors: lehmann jm. Diabetes. 1999 Jul;48(7):1415-24. doi: 10.2337/diabetes.48.7.1415. Diabetes. 1999. PMID: 10389847
74 results