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Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans.
Hinney A, Schmidt A, Nottebom K, Heibült O, Becker I, Ziegler A, Gerber G, Sina M, Görg T, Mayer H, Siegfried W, Fichter M, Remschmidt H, Hebebrand J. Hinney A, et al. Among authors: hebebrand j. J Clin Endocrinol Metab. 1999 Apr;84(4):1483-6. doi: 10.1210/jcem.84.4.5728. J Clin Endocrinol Metab. 1999. PMID: 10199800
Systematic mutation screening of the pro-opiomelanocortin gene: identification of several genetic variants including three different insertions, one nonsense and two missense point mutations in probands of different weight extremes.
Hinney A, Becker I, Heibült O, Nottebom K, Schmidt A, Ziegler A, Mayer H, Siegfried W, Blum WF, Remschmidt H, Hebebrand J. Hinney A, et al. Among authors: hebebrand j. J Clin Endocrinol Metab. 1998 Oct;83(10):3737-41. doi: 10.1210/jcem.83.10.5298. J Clin Endocrinol Metab. 1998. PMID: 9768693
No evidence for involvement of the leptin gene in anorexia nervosa, bulimia nervosa, underweight or early onset extreme obesity: identification of two novel mutations in the coding sequence and a novel polymorphism in the leptin gene linked upstream region.
Hinney A, Bornscheuer A, Depenbusch M, Mierke B, Tölle A, Middeke K, Ziegler A, Roth H, Gerber G, Zamzow K, Ballauff A, Hamann A, Mayer H, Siegfried W, Lehmkuhl G, Poustka F, Schmidt MH, Hermann H, Herpertz-Dahlmann BM, Fichter M, Remschmidt H, Hebebrand J. Hinney A, et al. Among authors: hebebrand j. Mol Psychiatry. 1998 Nov;3(6):539-43. doi: 10.1038/sj.mp.4000394. Mol Psychiatry. 1998. PMID: 9857981
No evidence for an involvement of alleles of polymorphisms in the serotonin1Dbeta and 7 receptor genes in obesity, underweight or anorexia nervosa.
Hinney A, Herrmann H, Löhr T, Rosenkranz K, Ziegler A, Lehmkuhl G, Poustka F, Schmidt MH, Mayer H, Siegfried W, Remschmidt H, Hebebrand J. Hinney A, et al. Among authors: hebebrand j. Int J Obes Relat Metab Disord. 1999 Jul;23(7):760-3. doi: 10.1038/sj.ijo.0800926. Int J Obes Relat Metab Disord. 1999. PMID: 10454111
Independent confirmation of a major locus for obesity on chromosome 10.
Hinney A, Ziegler A, Oeffner F, Wedewardt C, Vogel M, Wulftange H, Geller F, Stübing K, Siegfried W, Goldschmidt HP, Remschmidt H, Hebebrand J. Hinney A, et al. Among authors: hebebrand j. J Clin Endocrinol Metab. 2000 Aug;85(8):2962-5. doi: 10.1210/jcem.85.8.6852. J Clin Endocrinol Metab. 2000. PMID: 10946912
658 results