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Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans.
Hinney A, Schmidt A, Nottebom K, Heibült O, Becker I, Ziegler A, Gerber G, Sina M, Görg T, Mayer H, Siegfried W, Fichter M, Remschmidt H, Hebebrand J. Hinney A, et al. Among authors: remschmidt h. J Clin Endocrinol Metab. 1999 Apr;84(4):1483-6. doi: 10.1210/jcem.84.4.5728. J Clin Endocrinol Metab. 1999. PMID: 10199800
Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity.
Hinney A, Hohmann S, Geller F, Vogel C, Hess C, Wermter AK, Brokamp B, Goldschmidt H, Siegfried W, Remschmidt H, Schäfer H, Gudermann T, Hebebrand J. Hinney A, et al. Among authors: remschmidt h. J Clin Endocrinol Metab. 2003 Sep;88(9):4258-67. doi: 10.1210/jc.2003-030233. J Clin Endocrinol Metab. 2003. PMID: 12970296 Free article. Clinical Trial.
Ghrelin receptor gene: identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal stature.
Wang HJ, Geller F, Dempfle A, Schäuble N, Friedel S, Lichtner P, Fontenla-Horro F, Wudy S, Hagemann S, Gortner L, Huse K, Remschmidt H, Bettecken T, Meitinger T, Schäfer H, Hebebrand J, Hinney A. Wang HJ, et al. Among authors: remschmidt h. J Clin Endocrinol Metab. 2004 Jan;89(1):157-62. doi: 10.1210/jc.2003-031395. J Clin Endocrinol Metab. 2004. PMID: 14715843
Mutation analysis of the MCHR1 gene in human obesity.
Wermter AK, Reichwald K, Büch T, Geller F, Platzer C, Huse K, Hess C, Remschmidt H, Gudermann T, Preibisch G, Siegfried W, Goldschmidt HP, Li WD, Price RA, Biebermann H, Krude H, Vollmert C, Wichmann HE, Illig T, Sørensen TI, Astrup A, Larsen LH, Pedersen O, Eberlé D, Clément K, Blundell J, Wabitsch M, Schäfer H, Platzer M, Hinney A, Hebebrand J. Wermter AK, et al. Among authors: remschmidt h. Eur J Endocrinol. 2005 Jun;152(6):851-62. doi: 10.1530/eje.1.01917. Eur J Endocrinol. 2005. PMID: 15941924
Systematic mutation screening of the pro-opiomelanocortin gene: identification of several genetic variants including three different insertions, one nonsense and two missense point mutations in probands of different weight extremes.
Hinney A, Becker I, Heibült O, Nottebom K, Schmidt A, Ziegler A, Mayer H, Siegfried W, Blum WF, Remschmidt H, Hebebrand J. Hinney A, et al. Among authors: remschmidt h. J Clin Endocrinol Metab. 1998 Oct;83(10):3737-41. doi: 10.1210/jcem.83.10.5298. J Clin Endocrinol Metab. 1998. PMID: 9768693
No evidence for involvement of the leptin gene in anorexia nervosa, bulimia nervosa, underweight or early onset extreme obesity: identification of two novel mutations in the coding sequence and a novel polymorphism in the leptin gene linked upstream region.
Hinney A, Bornscheuer A, Depenbusch M, Mierke B, Tölle A, Middeke K, Ziegler A, Roth H, Gerber G, Zamzow K, Ballauff A, Hamann A, Mayer H, Siegfried W, Lehmkuhl G, Poustka F, Schmidt MH, Hermann H, Herpertz-Dahlmann BM, Fichter M, Remschmidt H, Hebebrand J. Hinney A, et al. Among authors: remschmidt h. Mol Psychiatry. 1998 Nov;3(6):539-43. doi: 10.1038/sj.mp.4000394. Mol Psychiatry. 1998. PMID: 9857981
426 results