Triple check for antigen specificity of B cells during germinal centre reactions.
Lindhout E, Koopman G, Pals ST, de Groot C.
Lindhout E, et al.
Immunol Today. 1997 Dec;18(12):573-7. doi: 10.1016/s0167-5699(97)01160-2.
Immunol Today. 1997.
PMID: 9425734
Somatic hypermutation of the immunoglobulin variable genes during germinal reactions might permit the expansion of B-cell clones with unwanted (e.g. autoreactive) specificity. Here, Ernst Lindhout and colleagues propose three antigen-specific checkpoints that ensure …
Somatic hypermutation of the immunoglobulin variable genes during germinal reactions might permit the expansion of B-cell clones with unwant …