Humphreys DP - Search Results

1

Mutations in dsbA and dsbB, but not dsbC, lead to an enhanced sensitivity of Escherichia coli to Hg2+ and Cd2+.

Stafford SJ, Humphreys DP, Lund PA. Stafford SJ, et al. Among authors: humphreys dp. FEMS Microbiol Lett. 1999 May 1;174(1):179-84. doi: 10.1111/j.1574-6968.1999.tb13566.x. FEMS Microbiol Lett. 1999. PMID: 10234837

2

Human protein disulfide isomerase functionally complements a dsbA mutation and enhances the yield of pectate lyase C in Escherichia coli.

Humphreys DP, Weir N, Mountain A, Lund PA. Humphreys DP, et al. J Biol Chem. 1995 Nov 24;270(47):28210-5. doi: 10.1074/jbc.270.47.28210. J Biol Chem. 1995. PMID: 7499315 Free article.

3

Co-expression of human protein disulphide isomerase (PDI) can increase the yield of an antibody Fab' fragment expressed in Escherichia coli.

Humphreys DP, Weir N, Lawson A, Mountain A, Lund PA. Humphreys DP, et al. FEBS Lett. 1996 Feb 12;380(1-2):194-7. doi: 10.1016/0014-5793(96)00028-2. FEBS Lett. 1996. PMID: 8603736 Free article.

4

A plasmid system for optimization of Fab' production in Escherichia coli: importance of balance of heavy chain and light chain synthesis.

Humphreys DP, Carrington B, Bowering LC, Ganesh R, Sehdev M, Smith BJ, King LM, Reeks DG, Lawson A, Popplewell AG. Humphreys DP, et al. Protein Expr Purif. 2002 Nov;26(2):309-20. doi: 10.1016/s1046-5928(02)00543-0. Protein Expr Purif. 2002. PMID: 12406686

5

Extending the half-life of a fab fragment through generation of a humanized anti-human serum albumin Fv domain: An investigation into the correlation between affinity and serum half-life.

Adams R, Griffin L, Compson JE, Jairaj M, Baker T, Ceska T, West S, Zaccheo O, Davé E, Lawson AD, Humphreys DP, Heywood S. Adams R, et al. Among authors: humphreys dp. MAbs. 2016 Oct;8(7):1336-1346. doi: 10.1080/19420862.2016.1185581. Epub 2016 Jun 17. MAbs. 2016. PMID: 27315033 Free PMC article.

6

Fab-dsFv: A bispecific antibody format with extended serum half-life through albumin binding.

Davé E, Adams R, Zaccheo O, Carrington B, Compson JE, Dugdale S, Airey M, Malcolm S, Hailu H, Wild G, Turner A, Heads J, Sarkar K, Ventom A, Marshall D, Jairaj M, Kopotsha T, Christodoulou L, Zamacona M, Lawson AD, Heywood S, Humphreys DP. Davé E, et al. Among authors: humphreys dp. MAbs. 2016 Oct;8(7):1319-1335. doi: 10.1080/19420862.2016.1210747. Epub 2016 Aug 17. MAbs. 2016. PMID: 27532598 Free PMC article.

7

Relative stabilities of IgG1 and IgG4 Fab domains: influence of the light-heavy interchain disulfide bond architecture.

Heads JT, Adams R, D'Hooghe LE, Page MJ, Humphreys DP, Popplewell AG, Lawson AD, Henry AJ. Heads JT, et al. Among authors: humphreys dp. Protein Sci. 2012 Sep;21(9):1315-22. doi: 10.1002/pro.2118. Epub 2012 Aug 9. Protein Sci. 2012. PMID: 22761163 Free PMC article.

8

Engineering an improved IgG4 molecule with reduced disulfide bond heterogeneity and increased Fab domain thermal stability.

Peters SJ, Smales CM, Henry AJ, Stephens PE, West S, Humphreys DP. Peters SJ, et al. Among authors: humphreys dp. J Biol Chem. 2012 Jul 13;287(29):24525-33. doi: 10.1074/jbc.M112.369744. Epub 2012 May 18. J Biol Chem. 2012. PMID: 22610095 Free PMC article.

9

F(ab')2 molecules made from Escherichia coli produced Fab' with hinge sequences conferring increased serum survival in an animal model.

Humphreys DP, Vetterlein OM, Chapman AP, King DJ, Antoniw P, Suitters AJ, Reeks DG, Parton TA, King LM, Smith BJ, Lang V, Stephens PE. Humphreys DP, et al. J Immunol Methods. 1998 Aug 1;217(1-2):1-10. doi: 10.1016/s0022-1759(98)00061-1. J Immunol Methods. 1998. PMID: 9776570

10

Formation of dimeric Fabs in Escherichia coli: effect of hinge size and isotype, presence of interchain disulphide bond, Fab' expression levels, tail piece sequences and growth conditions.

Humphreys DP, Chapman AP, Reeks DG, Lang V, Stephens PE. Humphreys DP, et al. J Immunol Methods. 1997 Dec 1;209(2):193-202. doi: 10.1016/s0022-1759(97)00172-5. J Immunol Methods. 1997. PMID: 9461335

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