Danishefsky SJ - Search Results

1

Synthesis and evaluation of geldanamycin-estradiol hybrids.

Kuduk SD, Zheng FF, Sepp-Lorenzino L, Rosen N, Danishefsky SJ. Kuduk SD, et al. Among authors: danishefsky sj. Bioorg Med Chem Lett. 1999 May 3;9(9):1233-8. doi: 10.1016/s0960-894x(99)00185-7. Bioorg Med Chem Lett. 1999. PMID: 10340605

2

Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones.

Moasser MM, Sepp-Lorenzino L, Kohl NE, Oliff A, Balog A, Su DS, Danishefsky SJ, Rosen N. Moasser MM, et al. Among authors: danishefsky sj. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1369-74. doi: 10.1073/pnas.95.4.1369. Proc Natl Acad Sci U S A. 1998. PMID: 9465021 Free PMC article.

3

Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel.

Chou TC, Zhang XG, Harris CR, Kuduk SD, Balog A, Savin KA, Bertino JR, Danishefsky SJ. Chou TC, et al. Among authors: danishefsky sj. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15798-802. doi: 10.1073/pnas.95.26.15798. Proc Natl Acad Sci U S A. 1998. PMID: 9861050 Free PMC article.

4

Probing cell-surface architecture through synthesis: an NMR-determined structural motif for tumor-associated mucins.

Live DH, Williams LJ, Kuduk SD, Schwarz JB, Glunz PW, Chen XT, Sames D, Kumar RA, Danishefsky SJ. Live DH, et al. Among authors: danishefsky sj. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3489-93. doi: 10.1073/pnas.96.7.3489. Proc Natl Acad Sci U S A. 1999. PMID: 10097062 Free PMC article.

5

A common pharmacophore for cytotoxic natural products that stabilize microtubules.

Ojima I, Chakravarty S, Inoue T, Lin S, He L, Horwitz SB, Kuduk SD, Danishefsky SJ. Ojima I, et al. Among authors: danishefsky sj. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4256-61. doi: 10.1073/pnas.96.8.4256. Proc Natl Acad Sci U S A. 1999. PMID: 10200249 Free PMC article.

6

Identification of a geldanamycin dimer that induces the selective degradation of HER-family tyrosine kinases.

Zheng FF, Kuduk SD, Chiosis G, Münster PN, Sepp-Lorenzino L, Danishefsky SJ, Rosen N. Zheng FF, et al. Among authors: danishefsky sj. Cancer Res. 2000 Apr 15;60(8):2090-4. Cancer Res. 2000. PMID: 10786665

7

Synthesis and evaluation of geldanamycin-testosterone hybrids.

Kuduk SD, Harris TC, Zheng FF, Sepp-Lorenzino L, Ouerfelli Q, Rosen N, Danishefsky SJ. Kuduk SD, et al. Among authors: danishefsky sj. Bioorg Med Chem Lett. 2000 Jun 5;10(11):1303-6. doi: 10.1016/s0960-894x(00)00208-0. Bioorg Med Chem Lett. 2000. PMID: 10866406

8

Total synthesis and antitumor activity of 12,13-desoxyepothilone F: an unexpected solvolysis problem at C15, mediated by remote substitution at C21.

Lee CB, Chou TC, Zhang XG, Wang ZG, Kuduk SD, Chappell MD, Stachel SJ, Danishefsky SJ. Lee CB, et al. Among authors: danishefsky sj. J Org Chem. 2000 Oct 6;65(20):6525-33. doi: 10.1021/jo000617z. J Org Chem. 2000. PMID: 11052097

9

Probing the SAR of dEpoB via chemical synthesis: a total synthesis evaluation of C26-(1,3-dioxolanyl)-12,13-desoxyepothilone B.

Chappell MD, Harris CR, Kuduk SD, Balog A, Wu Z, Zhang F, Lee CB, Stachel SJ, Danishefsky SJ, Chou TC, Guan Y. Chappell MD, et al. Among authors: danishefsky sj. J Org Chem. 2002 Nov 1;67(22):7730-6. doi: 10.1021/jo020180q. J Org Chem. 2002. PMID: 12398496

10

The microtubule-stabilizing agents epothilones A and B and their desoxy-derivatives induce mitotic arrest and apoptosis in human prostate cancer cells.

Sepp-Lorenzino L, Balog A, Su DS, Meng D, Timaul N, Scher HI, Danishefsky SJ, Rosen N. Sepp-Lorenzino L, et al. Among authors: danishefsky sj. Prostate Cancer Prostatic Dis. 1999 Jan;2(1):41-52. doi: 10.1038/sj.pcan.4500282. Prostate Cancer Prostatic Dis. 1999. PMID: 12496865

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